Post by account_disabled on Jan 1, 2024 22:44:44 GMT -5
Assoc. Prof. Dr. Ekaphob Sirachainan Each year cancer is a disease that takes the lives of many people. Data from the World Health Organization in 2018 reported that there were more than 9.6 million deaths worldwide from cancer, coming a little closer. In Thailand, cancer is the leading cause of death. 1There are 78,540 deaths per year, 122,757 new cases, and there is still a trend of continuous increase. And cancer doesn't just affect patients only. But it also affects the family and society around us in terms of body, mind, relationships, as well as affecting the economy and quality of life. With advances in medical technology and determination to research and find new ways to treat cancer, New continuously This led to the discovery of a new method of treating cancer called "Immunotherapy" Assoc. Prof. Dr. Ekaphob Sirachainan, Head of Oncology, Department of Internal Medicine Faculty of Medicine Ramathibodi Hospital explains that Immunotherapy or Immunotherapy is to use the body's immune system as a fighting unit to fight cancer. Normally, our body has white blood cells that play the main role in creating immunity, which is responsible for dealing with foreign substances in the body. White blood cells that play a key role in cancer immunity are called T-cells. Cancer cells are cells that have mutated and are considered foreign to the body as well. But cancer cells have the ability to evade immunity.
Ultimately causing cancer. Later, the mechanism by which cancer cells evaded the Job Function Email Database immune system was discovered. Therefore, it is possible to find a way to use immunity as a new way to treat cancer. What makes immunotherapy different from other types of cancer treatment is that it does not directly destroy cancer cells. but stimulates the body's immune system to destroy cancer cells again While undergoing chemotherapy Or targeted drugs have a direct effect on destroying cancer cells mainly. There are 3 main types of immunotherapy: antibodies, treatment cells, and cancer vaccines. But here I would like to talk about immunotherapy that uses antibodies that inhibit checkpoints or Checkpoint Inhibitors. 447441 Assoc. Prof. Dr. Ekaphob Sirachainan Checkpoint is a normal mechanism of body cells. Its function is to prevent excessive immune stimulation. Checkpoints on the surface of cancer cells and white blood cells bind to each other. It acts like a lock and key that prevents white blood cells from destroying cancer cells. Checkpoint inhibitors, which are antibody drugs, work to keep the lock and key from coming together. and gives white blood cells an opportunity to eliminate cancer cells Checkpoint inhibitors available in Thailand include CTLA-4 inhibitors, PD-1 inhibitors, and PD-L1 inhibitors. )
Checkpoint inhibitors have been shown to have research efficacy and are approved to treat many types of cancer, such as non-small cell lung cancer. melanoma skin cancer Bladder cancer and triple negative breast cancer, etc. However, checkpoint inhibitors cannot be used to treat all types of cancer. Because the indications for treatment of each type of cancer depend on the stage of the disease. and characteristics of the disease Patients can seek advice from medical professionals. Taking checkpoint inhibitors can also have side effects. This may cause inflammation of various organs. which is characterized by stimulation of the immune system Organs that often experience inflammation include the skin, which may have a rash or itching, the intestines, symptoms of diarrhea, abdominal pain, lungs, fatigue, coughing, liver, and abnormal blood values. Yellow body, yellow eyes and the endocrine system such as the pituitary gland and thyroid gland. Have symptoms of abnormal hormone deficiency or excess But most symptoms are mild to moderate. and can be edited These inflammatory symptoms can occur at any time.
Ultimately causing cancer. Later, the mechanism by which cancer cells evaded the Job Function Email Database immune system was discovered. Therefore, it is possible to find a way to use immunity as a new way to treat cancer. What makes immunotherapy different from other types of cancer treatment is that it does not directly destroy cancer cells. but stimulates the body's immune system to destroy cancer cells again While undergoing chemotherapy Or targeted drugs have a direct effect on destroying cancer cells mainly. There are 3 main types of immunotherapy: antibodies, treatment cells, and cancer vaccines. But here I would like to talk about immunotherapy that uses antibodies that inhibit checkpoints or Checkpoint Inhibitors. 447441 Assoc. Prof. Dr. Ekaphob Sirachainan Checkpoint is a normal mechanism of body cells. Its function is to prevent excessive immune stimulation. Checkpoints on the surface of cancer cells and white blood cells bind to each other. It acts like a lock and key that prevents white blood cells from destroying cancer cells. Checkpoint inhibitors, which are antibody drugs, work to keep the lock and key from coming together. and gives white blood cells an opportunity to eliminate cancer cells Checkpoint inhibitors available in Thailand include CTLA-4 inhibitors, PD-1 inhibitors, and PD-L1 inhibitors. )
Checkpoint inhibitors have been shown to have research efficacy and are approved to treat many types of cancer, such as non-small cell lung cancer. melanoma skin cancer Bladder cancer and triple negative breast cancer, etc. However, checkpoint inhibitors cannot be used to treat all types of cancer. Because the indications for treatment of each type of cancer depend on the stage of the disease. and characteristics of the disease Patients can seek advice from medical professionals. Taking checkpoint inhibitors can also have side effects. This may cause inflammation of various organs. which is characterized by stimulation of the immune system Organs that often experience inflammation include the skin, which may have a rash or itching, the intestines, symptoms of diarrhea, abdominal pain, lungs, fatigue, coughing, liver, and abnormal blood values. Yellow body, yellow eyes and the endocrine system such as the pituitary gland and thyroid gland. Have symptoms of abnormal hormone deficiency or excess But most symptoms are mild to moderate. and can be edited These inflammatory symptoms can occur at any time.